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GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes
Uenishi et al. (2024) JCI Insights 9. 6
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A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells
Cook et al. (2023) Molecular Therapy Journal 31. 8
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Generation of Islet-specific Engineered Regulatory T Cells (EngTregs) for Immune Tolerance Induction in Type 1 Diabetes Using a Novel Dual-editing Strategy
Peter J. Cook1, Martina S. Hunt1, Soo Jung Yang2, Emma Mortensen2, Jane Buckner2, David Rawlings1
1 Seattle Childrens Research Institute, Seattle, WA, 2 Benaroya Research Institute, Seattle, WA -
June 03, 2020
Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function
Honaker et al. (2020) Sci. Transl. Med. 12, eaay6422